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gene polymorphism and atopy in
Italian families
a Institute of Biology
and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona,
Italy, b Department of
Paediatrics, University of Verona, Italy
Correspondence to: Dr Trabetti.
Received 2 June 1998;
Revised version accepted for publication 28 August 1998
Tumour necrosis factor (TNF) is a proinflammatory cytokine
that increases human airway tissue responsiveness and is considered a
candidate gene for asthma. Two common polymorphisms
(LT
NcoI and TNF-308) in the TNF gene
complex were studied in 600 subjects from 131 Italian families with
atopic asthmatic children. Skin prick test (SPT), total IgE levels,
atopy (defined as increased IgE levels or SPT positivity or both),
bronchial hyperresponsiveness, and clinical asthma were investigated.
The observed distribution of the identical by descent alleles at the
LTNcoI locus was different from expected
for SPT and atopy (p=0.015). The LTNcoI
genotype distribution for increased IgE levels was different between
males and females (p=0.0011), and an association of the 2.2 genotype with increased IgE levels was observed in females (p=0.0032). The
results indicate that the LT gene, or a closely linked locus, is
associated with atopy, and suggest a sex difference in the effect of
the gene.
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