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a Department of Otorhinolaryngology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan, b Department of Otorhinolaryngology, Tokyo Kosei Nenkin Hospital, Tokyo 162, Japan, c Department of Otorhinolaryngology, Hamamatsu University School of Medicine, Hamamatsu 431-31, Japan, d Department of Otolaryngology, Otsu Red Cross Hospital, Otsu 520, Japan, e Department of Otolaryngology, Osaka University Faculty of Medicine, Suita 565-0871, Japan, f Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan, g Department of Otorhinolaryngology, Miyazaki Medical College, Miyazaki 889-16, Japan
Correspondence to: Professor Usami, Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
Revised version received 16 August 1999;
Accepted for publication 27 August
1999
The frequency of three mitochondrial point mutations,
1555A
G, 3243AG, and 7445AG, known to be associated with
hearing impairment, was examined using restriction fragment length
polymorphism (RFLP) analysis in two Japanese groups: (1) 319 unrelated
SNHL outpatients (including 21 with aminoglycoside antibiotic injection
history), and (2) 140 cochlear implantation patients (including 22 with aminoglycoside induced hearing loss). Approximately 3% of the outpatients and 10% of the cochlear implantation patients had the
1555AG mutation. The frequency was higher in the patients with a
history of aminoglycoside injection (outpatient group 33%, cochlear
implantation group 59%). One outpatient (0.314%) had the 3243AG
mutation, but no outpatients had the 7445AG mutation and neither
were found in the cochlear implantation group. The significance of the
1555AG mutation, the most prevalent mitochondrial mutation found in
this study of a hearing impaired population in Japan, among subjects
with specific backgrounds, such as aminoglycoside induced hearing loss,
is evident.
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