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J Med Genet 2001;38:232-233 ( April )

Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease

Alison E Taylora b, Agustin Yipa c, Carol Braynec, Douglas Eastond, John Grimley Evanse, John Xuerebf, Nigel Cairnsg, Margaret M Esirih, David C Rubinszteina

a Department of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK, b Department of Medical Genetics, Molecular Genetics Laboratory, Box 158 Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK, c Department of Public Health and Primary Care, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK, d CRC Genetic Epidemiology Unit, Cambridge University Department of Public Health and Primary Care, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK, e Department of Clinical Geratology, Radcliffe Infirmary, Oxford OX2 6HE, UK, f Department of Pathology, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK, g Medical Research Council Brain Bank, Department of Neuropathology, Institute of Psychiatry, London, De Crespigny Park, London SE5 8AF, UK , h Neuropatholology Department, Radcliffe Infirmary, Oxford OX2 6HE, UK

Correspondence to: Dr Rubinsztein, dcr1000{at}cus.cam.ac.uk

Revised version received 17 January 2001; Accepted for publication 18 January 2001

OBJECTIVES---The only locus unequivocally associated with late onset Alzheimer's disease (AD) risk is APOE. However, this locus accounts for less than half the genetic variance. A recent study suggested that the A allele of the 3'UTR biallelic polymorphism in the LBP-1c/CP2/LSF gene was associated with reduced AD risk. Samples were diagnosed predominantly by clinical rather than pathological criteria. We have sought to replicate this finding in a series of necropsy confirmed, late onset AD cases and non-demented controls.
METHODS---The 3'UTR polymorphism in the LBP-1c/CP2/LSF gene was typed in 216 necropsy confirmed AD cases and 301 non-demented controls aged >73 years.
RESULTS---We found different LBP-1c/CP2/LSF allele distributions in our AD cases and controls (p=0.048); the A allele was associated with reduced AD risk. The allele and genotype frequencies observed in our cases and controls were similar to those previously reported. No significant effects emerged when the data were adjusted for age, sex, or apoE epsilon 4 carrier status.
CONCLUSIONS---Our data support LBP-1c/CP2/LSF as a candidate gene/risk factor for AD and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.


Keywords: Alzheimer's disease; LBP-1c/CP2/LSF; dementia; MRC/CFAS study

© 2001 by J Med Genet


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